Am.  Jour.  Pharra.  ) 
July,  1909.  J 
Syrups. 
325 
experimented  on  formulas  for  the  various  pharmaceutical  prepara- 
tions. It  was  found  that  rluidextract  could  be  prepared  by  either 
of  the  two  following  methods : 
Ground  buckthorn  berries   1000  Gms. 
Alcohol    250  Gms. 
Water,  a  sufficient  quantity. 
Add  the  ground  buckthorn  berries  to  five  litres  boiling  water, 
allow  to  infuse  for  two  hours  and  then  express.  Again  infuse  the 
dregs  with  three  litres  of  boiling  water  and  express.  Mix  the  ex- 
pressed liquids  and  evaporate  to  750  c.c.  When  cold  add  250  c.c. 
alcohol  and  allow  to  stand  for  a  few  days,  then  filter,  and  wash 
the  filter  with  sufficient  of  a  mixture  of  alcohol  1  volume,  water 
3  volumes,  to  make  1000  c.c.  Or  a  very  satisfactory  rluidextract 
can  also  be  prepared  by  the  official  method,  using  diluted  alcohol 
as  the  menstruum  and  reserving  the  first  850  c.c.  of  percolate  to  each 
litre  of  product.  Percolation  with  weaker  alcohol  was  not  practical 
owing  to  the  gummy  character  of  the  drug. 
Fluidglycerate  of  buckthorn  can  be  prepared  by  the  type  process,7 
but  the  percolation  is  very  slow  and  tedious. 
Syrup  of  Buckthorx. — Several  methods  were  tried  for  the 
making  of  the  syrup — infusion,  percolation  with  glycerin  and  water, 
rluidextract  diluted  with  syrup,  and  fluidglycerate  diluted  with 
syrup.  All  of  these  yielded  apparently  good  results.  Buckthorn 
berries  are  apt  to  produce  griping,  and  to  prevent  this  an  aromatic 
is  usually  associated  as  a  corrective.  In  the  formula  submitted  oil 
of  fennel  and  oil  of  cassia  are  used  for  this  purpose. 
The  following  formula  is  recommended  for  the  revision  of  the 
National  Formulary: 
Buckthorn  berries,  ground    200  Gms. 
Sugar   800  Gms. 
Oil  of  fennel   2  c.c. 
Oil  of  cassia  2  c.c. 
Water,  a  sufficient  quantity. 
Add  the  ground  buckthorn  berries  to  two  litres  of  boiling  water, 
infuse  for  two  hours,  and  then  express.  Infuse  the  dregs  with  500 
c.c.  boiling  water  and  express  when  cold.   3. fix  the  expressed  liquids, 
7  See  Proceedings  A.  Ph.  A.,  1908,  p.  981.    Amer.  Jour.  Pharm.,  1908, 
