Am.  Jour.  Pharm.) 
July,  1909.  ( 
Pepsin. 
335 
"  The  introduction  of  therapeutic  or  anatomical  names  in  the  future 
should  be  prohibited,  and  we  recommend  that  present  therapeutic 
titles  be  eliminated  as  far  as  is  practicable." 
An  examination  of  the  present  N.F.  formulas  shows  that  in  the 
Compound  Powder  of  Pepsin  pancreatin  is  in  excess  and  the  pepsin 
is  insufficient.  In  framing  the  formula  for  Compound  Elixir  of  Pepsin 
the  pancreatin  was  reduced  to  I  gramme  per  litre  and  the  pepsin 
increased  to  10  Gm.  The  elixir  bears  no  relation  to  the  powder 
either  in  the  relative  proportion  of  the  ingredients  or  in  representing 
a  definite  weight  of  the  powder  in  a  stated  volume  of  product.  One 
of  the  strongest  claims  made  by  the  pharmaceutical  manufacturers  is 
that  their  lactated-pepsin  elixirs  represent  40  or  80  grains  of  com- 
pound powder  of  pepsin  to  the  fluidounce  and  this  carries  weight 
with  the  practitioner  and  meets  his  desire.  Other  minor  defects  are 
the  reduction  in  the  amount  of  acids  directed  and  insufficient  flavor- 
ing due  to  the  use  of  aromatic  elixir  instead  of  adding  the  oils  direct 
as  flavoring  in  the  course  of  preparation.  Orange  is  the  accepted 
flavor  which  appears  to  be  used  by  all  the  manufacturers  and  should 
be  retained  in  the  Formulary.  The  use  of  tincture  of  cudbear  as 
a  coloring  introduces  some  variability  in  the  color  of  products  as 
made  by  different  druggists  due  to  the  impossibility  of  entirely 
exhausting  cudbear  in  making  the  tincture  and  the  varying  degree 
of  successful  exhaustion  in  the  preparation  by  different  manipulators. 
In  the  formula  submitted  herewith  it  is  proposed  to  have  the 
elixir  approximately  represent  one-tenth  of  the  powder,  or  100  Gm. 
of  Compound  Powder  of  Pepsin  in  1  litre  of  elixir.  The  flavoring 
is  orange  and  by  the  use  of  powdered  cudbear  a  greater  uniformity 
in  product  of  different  stores  will  be  secured. 
The  following  proposed  formula  is  submitted  for 
Elixir  Pepsini  Compositum. 
Compound  Elixir  of  Pepsin. 
Pepsin  (soluble  "scale  or  granular"  variety)   15  Gm. 
Pancreatin    15  Gm. 
Diastase    1  Gm. 
Lactic  acid   1  c.c. 
Hydrochloric  acid    2  c.c. 
Glycerin    250  c.c. 
Alcohol   200  c.c. 
Oil  orange   2  c.c. 
Cudbear    1  Gm. 
Water,  a  sufficient  quantity  to  make  1000  c.c. 
