Am.  Jour.  Pharni.  ) 
October,  1909.  j 
Fluidgly  cerates. 
475 
SOME  FURTHER  WORK  ON  FLUIDGLYCERATES  * 
By  George  M.  Beringer. 
In  two  previous  papers 1  dealing  with  the  subject  of  fluid- 
glycerates, the  writer  has  given  an  account  of  experiments  on  the 
extraction  of  various  drugs  with  glycerol-water  menstruums  and 
the  preparation  of  a  number  of  concentrated  liquids  representing 
this  proposed  new  class  of  galenicals. 
The  manufacture  of  a  few  of  these  fluidglycerates  on  a  moderate 
scale  has  been  attempted,  and  the  practical  use  by  physicians  already 
indicates  that  such  fluidglycerates  as  cascara  sagrada,  chirata,  glycyr- 
rhiza,  krameria,  sumach  berries,  and  sarsaparilla  are  acceptable 
preparations,  and  further  efforts  will  probably  demonstrate  that  this 
list  of  useful  remedies  of  this  class  may  be  greatly  extended. 
In  a  recent  communication  presented  to  the  New  Jersey  Pharma- 
ceutical Association,2  the  results  Of  experiments  made  with  the  view 
of  studying  the  application  of  the  principle  of  glycerol-water  extrac- 
tion to  the  preparation  of  syrups  are  described.  It  was  shown  that 
quite  a  number  of  syrups  can  be  thus  prepared  direct  from  the  drugs 
without  the  use  of  fluidextracts  or  the  introduction  of  any  alcohol. 
Those  for  which  improved  formulas  based  on  this  method  were  pre- 
sented and  samples  exhibited  included  syrups  of  ipecac,  krameria, 
lactucarium,  rhubarb,  rose,  rubus,  compound  sarsaparilla,  compound 
squill,  senega,  and  licorice. 
In  the  extensive  paper  on  ,f  Fluidglycerates  "  presented  before 
this  section  last  year,  it  was  explained  that  the  experiments  so  far 
made  on  the  preparation  of  fluidglycerates  of  certain  drugs  were  not 
satisfactory,  and  further  experimentation  was  intended.  Among  the 
refractory  drugs  so  mentioned  were  nux  vomica,  red  rose,  and  san- 
guinaria.  Experiments  since  carried  on  with  these  three  have  re- 
sulted in  marked  improvements.  The  purpose  of  the  present  paper 
is  to  communicate  improved  formulas  for  these  and  also  to  present 
the  results  of  some  experiments  upon  a  few  fluidglycerates  of  a 
different  class  of  drugs  that  require  for  their  extraction  the  use  of 
an  alkali  in  the  menstruum. 
*  Read  at  the  Section  on  Practical  Pharmacy  and  Dispensing  of  the 
American  Pharmaceutical  Association,   September,  1909. 
1  Proceedings  N.  J.  Phar.  Assoc.,  1907,  p.  56.  Proceedings  Amer.  Pharm. 
Assoc.,  1908,  p.  981. 
2  American  Journal  of  Pharmacy,  1909,  July,  p.  311. 
