Am.  Jour.  Pharm.  ) 
October,  1909.  j 
Fluid glycerates. 
477 
reserve,  and  continue  the  evaporation  till  the  product  measures 
IOO  c.c. 
Fluidglycerate  of  Red  Rose. — It  was  intimated  in  my  previous 
paper  that  the  addition  of  an  acid  to  the  menstruum  would  possibly 
improve  this  preparation.  Sulphuric  acid  seems  to  fix  the  color  of 
rose  and  to  be  specially  indicated  in  the  liquid  preparations  of  that 
drug.  The  following  is  the  improved  formula  for  fluidglycerate 
of  rose : 
Take  of  Red  rose  in  No.  60  powder   100  Gm. 
Diluted  sulphuric  acid    10  c.c. 
Glycerin   50  c.c. 
Distilled  water    140  c.c. 
Chloroform  water,  a  sufficient  quantity. 
Mix  the  acid,  glycerin,  and  water,  and  having  thoroughly  mixed 
the  rose  with  300  Gm.  of  clean,  pure  white  sand,4  moisten  it  with 
80  c.c.  of  this  menstruum  and  transfer  to  a  percolator,  shaking  down 
evenly  but  not  packing.  Pour  on  sufficient  of  the  menstruum  to  sat- 
urate the  drug  and  allow  to  macerate  for  forty-eight  hours,  then 
percolate  slowly,  using  the  remainder  of  the  menstruum  and  then 
chloroform  water  till  extracted.  Reserve  the  first  50  c.c.  of  per- 
colate and  evaporate  the  remainder  on  the  water-bath  to  60  c.c,  add 
the  reserve,  and  concentrate  to  100  c.c.  The  product  is  a  deep  rich 
red  color,  clear,  astringent,  and  with  a  fine  aroma  and  taste  of  rose. 
It  mixes  perfectly  clear  with  water,  syrup,  or  diluted  alcohol,  but 
is  coagulated  by  alcohol.  It  would  make  a  good  basic  preparation, 
as  it  can  be  diluted  for  making  a  syrup,  gargle,  or  mouth  wash 
where  rose  is  desirable. 
Fluidglycerate  of  Sanguinaria. — This  is  a  difficult  drug  to 
extract  and  represent  in  a  concentrated  liquid  preparation  that  will 
be  permanent  and  active.  For  some  reason,  acetic  acid  has  been 
considered  as  particularly  well  adapted  for  its  extraction,  and  this  is 
evidenced  in  the  official  fluidextract  and  in  the  formulas  for  the  syrup 
and  vinegar.  Quite  naturally  the  writer  followed  this  idea  in  his 
experiments,  and  in  the  formula  submitted  last  year  acetic  acid  was 
used  but  it  was  stated  that  the  product  was  not  satisfactory,  as  it 
4  For  this  purpose  sand  free  from  iron  is  necessary,  and  the  purest  com- 
mercial white  sand  obtainable  was  boiled  with  diluted  hydrochloric  acid  and 
then  washed  by  decantation  and  finally  on  a  strainer  till  the  wash  water 
ceased  to  give  a  precipitate  with  silver  nitrate  T.  S. 
