478 
Fluidgly  cerates. 
("Am.  Jour.  Pharni 
\     October,  1909. 
had  developed  considerable  sediment  and  did  not  mix  clear  with 
water  or  syrup. 
Subsequently  experiments  were  made  with  varying  proportions 
of  acetic  acid.  Somewhat  better  results  were  obtained  by  increasing 
the  acetic  acid  to  30  c.c.  in  100  c.c.  of  product  and  using  this  mixed 
with  50  c.c.  of  glycerin  and  120  c.c.  of  water  as  the  first  menstruum. 
But  even  with  this  relatively  large  acid  content  the  product  soon 
became  cloudy  and  deposited  considerable  sediment,  although  its 
miscibility  with  other  liquids  was  improved.  It  mixed  clear  with 
syrup  and  diluted  alcohol  and  produced  only  an  opalescence  with 
water,  but  with  alcohol  it  became  turbid. 
Since  acetic  acid  did  not  prove  satisfactory,  my  attention  was 
directed  to  the  use  of  hydrochloric  acid.  The  experiments  indicate 
that  it  has  decided  advantage  over  acetic  acid  for  extracting  this 
drug  and  suggest  that  its  use  in  this  connection  should  be  investi- 
gated, as  it  appears  to  offer  an  improvement  in  the  formulas  for  the 
official  preparations  of  the  same. 
The  following  is  the  improved  formula  for  fluidglycerate  of 
sanguinaria : 
Take  of  Sanguinaria  in  No.  20  powder   100  Gm. 
Hydrochloric  acid    10  c.c. 
Glycerin   50  c.c. 
Water    140  c.c. 
Chloroform  water,  a  sufficient  quantity. 
Mix  the  acid,  glycerin,  and  water,  and  moisten  the  drug  with 
50  c.c.  of  the  mixture,  transfer  to  a  percolator,  and  shake  down 
evenly,  without  packing,  and  pour  on  sufficient  of  the  menstruum 
to  saturate  and  allow  to  macerate  for  forty-eight  hours.  Then  per- 
colate slowly,  using  the  remainder  of  the  menstruum  and  then  chlo- 
roform water  till  extracted.  Reserve  the  first  50  c.c.  of  the  percolate 
and  evaporate  the  remainder  to  60  c.c,  add  the  reserve,  and  concen- 
trate to  100  c.c. 
This  product  is  clear  dark  red  in  color,  and  after  standing  three 
months  has  shown  no  tendency  to  precipitation.  It  mixes  clear  with 
syrup,  diluted  alcohol,  and  alcohol,  and  with  water  produces  a  slight 
opalescence.  It  possesses  the  bitter,  acrid,  and  irritating  taste  of  the 
drug,  and  the  smallest  amount  tasted  produced  the  disagreeable 
irritating  effect  on  the  mucous  surfaces.  The  physical  characteris- 
tics of  the  fluidglycerate  so  made  appear  to  fully  represent  the  drug 
