Am.  Jour.  Pharin  f 
October,  1909.  j 
Fluidglycerates^ 
479 
and  the  marc  is  free  from  acridity  and  is  deprived  of  the  red  color. 
Alkaline  Fluidglycerates. — There  are  a  number  of  drugs 
that  require  the  presence  of  an  alkali  for  their  proper  extraction. 
In  the  previous  paper  three  fluidglycerates  of  this  class  of  drugs 
were  considered,  namely,  fluidglycerates  of  glycyrrhiza  and  senega 
and  the  bitterless  fluidglycerate  of  cascara.  Three  more  of  this 
class  have  been  investigated  since,  viz.,  buchu,  eriodictyon,  and 
grindelia,  and  formulas  for  these  are  here  given. 
FLUIDGLYCERATE  OF  BUCHU. 
Take  of  Buchu  in  No.  20  powder   100  Gm. 
Solution  of  potassium  hydroxide   50  c.c. 
Glycerin    50  c.c. 
Water    100  c.c. 
Chloroform  water,  a  sufficient  quantity. 
Mix  the  solution  of  potassium  hydroxide,  glycerin,  and  water 
and  moisten  the  drug  with  100  c.c.  of  this  menstruum.  Transfer  to 
a  percolator  and  shake  down  evenly,  then  pour  on  sufficient  of  the 
menstruum  to  thoroughly  saturate.  Allow  to  macerate  for  forty- 
eight  hours  and  then  percolate  slowly,  using  the  remainder  of  the 
menstruum  and  then  chloroform  water  till  extracted.  Reserve  the 
first  50  c.c.  of  the  percolate  and  evaporate  the  remainder  on  a  water- 
bath  to  60  c.c,  add  the  reserve,  and  concentrate  to  100  c.c.  This 
product  is  a  thick,  almost  mucilaginous  fluid  that  has  deposited  no 
sediment.  It  possesses  the  odor  and  taste  of  the  drug,  It  mixes 
clear  with  syrup  and  diluted  alcohol  and  opalescent  with  water,  and 
is  coagulated  by  alcohol. 
FLUIDGLYCERATE  OF  ERIODICTYON. 
Take  of  Eriodictyon  in  No.  20  powder   100  Gm. 
Solution  sodium  hydroxide    50  c.c. 
Glycerin    50  c.c. 
Water    100  c.c. 
Chloroform  water,  a  sufficient  quantity. 
Mix  the  solution  of  sodium  hydroxide,  glycerin,  and  water  and 
moisten  the  yerba  santa  with  80  c.c.  of  the  mixture.  Proceed  to 
extract  and  finish  as  directed  in  the  formula  for  fluidglycerate  of 
buchu.  The  resulting  preparation  has  the  color,  taste,  and  odor  of 
yerba  santa  and  has  developed  only  a  scant  sediment.    It  mixes 
