480 
Headache  Mixtures. 
f  Am.  Jour.  Pharm. 
\     October,  1909. 
clear  with  syrup  and  diluted  alcohol,  and  with  water  produces  only 
a  slight  opalescence,  but  with  alcohol  a  turbid  mixture  results. 
In  this  preparation  sodium  hydroxide  has  been  selected  because 
its  principal  use  will  be  as  a  disguise  for  quinine  sulphate  and  other 
bitter  alkaloids  and  drugs,  and  sodium  sulphate  resulting  in  such 
mixtures  is  less  apt  to  crystallize  out  than  if  potassium  hydroxide 
was  used  with  potassium  sulphate  as  a  resultant.  It  will  serve  as 
a  basic  preparation  for  syrup  of  yerba  santa  and  for  admixture  with 
chocolate  syrup  and  similar  flavorings  and  diluents. 
FLUIDGLYCERATE  OF  GRINDELIA. 
Take  of  Grindelia  in  No.  20  powder   100  Gm. 
Solution  of  potassium  hydroxide   50  c.c. 
Glycerin    50  c.c. 
Water    100  c.c. 
Chloroform  water,  a  sufficient  quantity. 
Proceed  exactly  as  directed  in  the  formula  for  fluidglycerate  of 
buchu. 
The  product  is  a  clear,  deep  brown  colored  liquid  possessing 
strongly  the  odor  and  taste  of  grindelia  and  showing  no  precipitate. 
It  mixes  clear  with  water,  syrup,  diluted  alcohol,  and  cloudy  with 
alcohol. 
There  is  already  considerable  demand  for  the  so-called  "  aque- 
ous "  or  "  soluble  "  fluidextract  of  grindelia  as  a  topical  application 
in  rhus  poisoning,  and  this  alkaline  fluidglycerate  will  doubtless 
prove  equally  as  effective  for  this  purpose. 
CO-OPERATIVE  WORK  , ON  HEADACHE  MIXTURES.* 
By  W.  O.  Emery. 
After  making  investigations  of  various  suggested  methods  for 
determining  the  different  constituents  present  in  the  many  headache 
mixtures  containing  acetanilid  and  similar  agents,  a  method  was 
finally  devised  which  proved  quite  satisfactory  to  the  members  of 
the  Division  of  Drugs,  and  it  was  therefore  decided  to  place  this 
*  Reprint  from  the  Proceedings  of  the  Twenty-fifth  Annual  Convention 
of  the  Association  of  Official  Agricultural  Chemists  (1908),  Bui.  122,  Bureau 
of  Chemistry.  U.  S.  Dept.  of  Agriculture. 
