340 BUHACHIRO TASAKI AND USHIO TANAKA. 
Time Ai R. Im Symptoms 
°_0/ 40.0 | 12 78 Coughing. 
SU == — — Tearing stops. 
°_0/ 39.82) 215 84. _ 
2572 i = == Defeecation (fees 3 boli, soft). 
10°-0/ 39.8 | 26 12 Symptoms of dyspnoa. 
11°-30/ | 39.3 | 32 72 Defzecation (feces 13 boli, muddy), strong dyspnoea, sometimes 
accompanied with nausea. 
12°-25/ | 39.8 | 54 84 Strong dyspnoea, wind sound of nose to be heard distinetly, 
neck stretching forward with nose reaching to the ground, 
strong nansea. 
407 | — — — Defzxcation (faces 13 boli, muddy, smelling badly, mixed with 
pseudmembranes). 
1°10 — — — Watery diarrhcea (2 litres). 
40/ | 39.4) 51 75 Defiecation (feces 15 boli, muddy), nausea frequent, great 
difficulty in breathing, movement of the abdominal walls to 
be seen markedly, nasal sound being very loud, moistness 
of mucosa increased, frequent smacking with the tongue, 
very disturbed, and presenting a pitiful appearance. 
°_0/ = = ooo Taking hay, but mastication listless, peristalsis to be heard 
only on the left, indistinctly. 
°_30/ | 38.3 | 30 66 Urination (urine 1 litre, very dilute), heavy staggering of the 
hind part of the body, taking hay promptly. 
6°-30/ | 38.3 26 60 Defxcation (feeces 8 boli, soft, mixed with pseudmembranes). 
45/ | —- a — Becoming very excited, frequently pawing, nasal sound being 
high, sweat secretion begins on the upper scapulal region 
and drops along abdomen and thigh. 
55’ | — — _ Urination (urine 3.5 litres). 
8-0/ 38.0 | 22 66 Very sensitive, pupils dilated, Hank region and ribs very sensi- 
tive, hind legs frequently change position to shift body 
weight. 
10°45/ | — _ _ Urination (urine 2 litres). 
From now on, all symptoms gradually disappear and at 5 o’clock in the afternoon he had 
recovered. 
In general, the symptoms began 1 hour and 15 minutes after taking the 
bark and ended after about 22 hours, showing (1) rise of temperature, (2) 
dyspnoea, (3) increase of secretions and excretions and (4) paralysis of hind 
part of body. This experiment shows clearly the existence of some toxic in- 
gredient in the bark, as has already been ascertained by several writers. 
