ON THE TOXIC CONSTITUENTS IN THE BARK OF ROBINIA PSEUDACACIA L. 351 
The symptoms coincide with those of the preliminary experiment: fre- 
quent evacuation to diarrhoea, paralysis of hind parts of body, dyspneea, 
hypereemy and humidity of visible mucous membrancs. The reaction caused 
by robitin varies in its degree not only according to the dosage, but also 
according to the individuality of the horse, that is, early or late appearance 
of symptoms, rapidity or slowness of effect and slightness or seriousness of 
degree. Between two horses similarly treated with robitin, the one which was 
given some excercise showed more serious symptoms, and the rezovery was 
slower than in the other. If we inject intravenously 0.15 grams of robitin per 
100 kilos. of horse body weight, the symptoms begin to show at 5 to 10 
minutes after the injection and end at 40 to 60 minutes. After 5 to 6 hours, 
spirits and appetite recover, but the state of faeces continues for about 20 hours. 
After the subcutaneous injection, some horses show similar reaction to 
that of the intravenous with same dosage, but generally the former syniptoms 
are inferior in degree to the latter at the rate of 1:5. / 
Internal administration of robitin as bolus or solutio causes the same 
reaction to the horse as intravenous injection, but only in very large dosage. 
Example I. November 25th, 1916. 
Name of horse: Yokonami, 17 years old. Body weight 360 kilos. Nutrition good. 
Time I: ; R. iD: Symptoms. 
9° 30/7 | 37.0 9 41 Normal. 
al — _ _ Robitin 1 gram in 5% solution intravenously. 
6 | — — — Hind part of body weak. 
7); — 19 — Evacuation (faeces 30 boli, normal but small shaped.) 
11/7 | — _ — Defeecation (feeces about 30 boli, surface a little moist.) 
20/ | 38.5) 21 45 = 
25/ | — — — Defeecation (faeces 40 boli, soft.) 
307 | — — = Visible mucous membranes moisten, legs gathering under the 
abdomen, hind parts of body stagger strongly. 
Scale er — Cough, 
38’ | 8385| 21 48 » 
40/ = = — os (many times), 
POLE - — 3 (2 times, short and humid). 
