A. Hunter and W. R. Campbell 189 
TABLE II. 
Comparison of Average Creatine Contents of Urine and Plasma. 
Plasma creatine Uiinary 
No. of er eL02 cee creatine 
cases. So) ares per 
or- | 100cc. 
Found.| vected. 
Description of group. 
A. Grouping determined by case classification. 
mg. mg. mg. 
PA Ee OIMIEOU DEL leo a) ie ues os 1 oo Lol tae 0187 |) .2.5 
PMOMET Te SMM et oo ie BR os od sh ayn a 40 1.64 | 0.41 2.9 
SR LP PEELOOC UNG KOO gi) opps sas» Gy eatin eee pal GG O42 5.0 
UPR CEIGICS kc ence dts cc ores 29 el 70 420-421 3. 1 
Peet cmales and-femules)y.0 30. 1 Soe ae. 189) Les Order 14:4 
INL SE RUGA GS oa Bee oO RE ee Se bene Ba read 54 | 1.85 | 0.46] 8.6 
Females of Group II........ Biden: Weeridi ne okh 3 7 | 2.43 | 0.61 | 31.4 
EIS TE COP OSE ia eg nae ts ee fare he sees TAS 2 45 OBL 254 0 
Crore LULA Ce cr te.) Ot es sot os tae Sack € cl 2547 eR OVGISIBE LEO 
B. Grouping determined by concentration of urinary creatine. 
Prines ereatine-(ree. ee ee ook clin ok ie coe WL. oo WO.40 cba 
BemCOltaiolie lesseinanOing ) eo «ola: 9 | 1.62] 0.41] 4.8 
re ey any creatine whatever....... Dewan 020 0 oltigto rs 
- 4 more*thanlOme..:. 8.7107. PEP e234 07596 2927 
strated one point more; the existence, namely, of a threshold for 
creatine, the level of which they would have fixed sharply at 
0.4 mg. per 100 cc. But the unreliability of the determination 
renders exceedingly doubtful the significance of a quantity as 
small as that. Indeed the extreme lowness of the threshold in- 
‘dicated (it would be surprisingly low even if the original figures 
needed no correction) is enough in itself to throw suspicion upon 
its reality. Thresholds of established importance, like those of 
glucose and chlorides, seem to be generally of much greater mag- 
nitude. The idea that there may be a normal constant of this 
sort for creatine receives moreover, it must be admitted, no 
support from the results of Wilson and Plass,!* who. used a 
method of analysis presumably more accurate than ours. The 
figures they present indicate rather the complete absence of 
creatine from the plasma in cases where the urine is ordinarily 
. creatine-free, and its presence in those only where creatinuria 
