THE INFLUENCE OF THYROID FEEDING UPON CAR- 
BOHYDRATE METABOLISM. I. 
THE STORAGE AND MOBILIZATION OF THE LIVER GLYCOGEN 
IN THYROID-FED ANIMALS. 
By SHIGENOBU KURIYAMA. 
(From the Sheffield Laboratory of Phystological Chemistry, Yale University ty 
New Haven.) 
(Received for publication, November 24, 1917.) 
An earlier paper! dealt chiefly with the influence of thyroid 
feeding upon the glycogen content of the liver and the sugar 
content of the blood. In the present series, I have investigated 
the glycogenetic and glycogenolytic action. of the liver of thy- 
roid-fed animals, the influence of thyroid feeding upon the liver 
glycogen of frogs, the interrelations of the thyroid and adrenals, 
acidosis after thyroid feeding, and the influence of alkali upon 
the diminished content of liver glycogen of thyroid-fed animals. 
Desiccated thyroid (Parke, Davis and Company) was usually 
fed, although fresh pig thyroid was used in one series of experi- ' 
ments. The methods employed for feeding and for determining 
the liver glycogen and the sugar of the blood or urine were the 
same as described in the first paper,! unless otherwise specified. 
The Formation of Liver Glycogen in Thyroid-Fed Rats upon a Very 
High Carbohydrate Diet. 
The glycogen content of the liver is rapidly decreased to the minimum 
by thyroid feeding, and is readily restored by omitting thyroid tissue 
from the diet. On the other hand, the liver of the thyroid-fed animals 
apparently does not increase its glycogen content as easily as that of 
fasted rats after parenteral administration of dextrose.! The increased 
need for energy-producing materials in hyperthyroidism may be the 
only cause of these phenomena, or it may also be that the glycogenetic or 
glycogenolytic action of the liver is somewhat affected. Though in vivo the 
1 Kuriyama, 8., Am. J. Physiol., 1917, xliii, 481. 
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THE JOURNAL OF BIOLOGICAL CHEMISTRY, VOL. XXXIII1, NO. 1 
