S. Kuriyama 197 
interchange, Magnus-Levy,” Thiele and Nehring, and Salomon" 
reported that both healthy men and myxedema patients treated 
with thyroid substance and also patients with Graves’ disease 
show an increase of 20 to 80 per cent in the amount of oxygen 
consumed. In experimental hyperthyroidism under the present 
conditions this inerease may be much higher. Although no 
diarrhea was evident in my experiments, digestibility of a very 
high carbohydrate diet must also be taken into consideration. The 
oft reported decrease of the assimilation limit of carbohydrate 
TABLE II. 
The Formation of Liver Glycogen by Administration of a Certain Amount of 
Food in Fasted Rats. 
Date UUs istic x Mad bese vw as I II Til IV V VI VII 
OGY IWelg hte Git. noe oak, 204.0) 224.0) 150.0) 255.0} 250.0) 207. 0 219.5 
Food aiters|, Paste, gis...) 2:0|4 0.5 “0 0 
72 hour 0 0 0 
fasting Sucrose, gm..| 0 Pei e 20) 65.0 
period. Mima aaa eiactloaa Bio 
Calories...... TOSO) eS. (i S.2h 20.5 0 0 0 
Loss of body weight, gm....|—19.8|—25.7|—30.0/—38.0} —48.0| —24.5| —22.0 
ee] ad A 
Weight, gm....... 6.0'536,2\-94.2| | 6:9 4.5 5.3 4.9 
TipetaleClncoren {[mg.....| 189.0) 322.4} 216.1) 399.6 
ae Trace. 0 | Trace. 
POM” | ver cent} 3.2) 5.2| 5.2) 5.8 
in Graves’ disease does not seem to be so great and is not always 
an accompanying symptom. From my experiments, it will be 
seen that under suitable conditions, the liver of thyroid-fed rats 
can store a certain amount of glycogen. Whether the remarkable 
difference between the thyroid-fed and fasted animals in forming 
the liver glycogen is due only to an increase of general metabolism 
cannot yet be clearly answered. 
12 Magnus-Levy, A., Berl. klin. Woch., 1895, xxii, 650; Deutsch. med. 
Woch., 1896, xxii, 491. 
13 Thiele, O., and Nehring, O., Z. klin. Med., 1896, xxx, 41. 
~14 Salomon, H., Berl. klin. Woch., 1904, xl, 635. 
