S. Kuriyama Zi 
was increased. On the other hand, the desiccated adrenal of the 
thyroid-fed animals had a higher adrenal content than the same 
amount of desiccated normal adrenal. This seems to show that 
the increase of the adrenal weight was mostly due to the water 
content and not to the solid substance. Obtaining the blood of 
the adrenal vein of dogs, into which extracts of various organs 
had been previously injected, and testing the vasoconstrictor 
action of this blood sample with another dog, Gley and Quin- 
quaud?® concluded that though the extracts of various organs can 
augment the secretion of epinephrine, the extract of thyroid 
gland is not specific. Gley’s other experiments!® demonstrate 
that the epinephrine content of the adrenal of thyroidectomized 
dogs and rabbits is not lower than that of normal animals. This 
is not in harmony with the results of Herring with thyroidecto- 
mized cats.® . 
Though an augmented secretion of epinephrine in hyperthy- 
roidism may be probable, the frequently reported intimate rela- 
tion between the hormones of the thyroid and adrenal has also 
been studied from different standpoints. Macleod and Pearce 
observed that after complete dissection of the hepatic plexus, 
stimulation of the splanchnic nerve is only occasionally followed 
by an increase in the sugar content of the vena cava blood, 
although a marked hyperglycemia is found in cases of the intact 
hepatic plexus. They therefore concluded that there was no 
evidence that hyperglycemia, caused by stimulation of splanchnic 
" nerve, is due to a hypersecretion of epinephrine. Oswald” dem- 
onstrated that though intravenous injection of iodothyreoglobulin 
has no effect on the circulation, this treatment increases the 
effectiveness of epinephrine in raising and maintaining blood pres- 
sure. Asher,!® Richardson,’ Kakehi, and EHiger!® reported that 
*Gley, E., and Quinquaud, A., Arch. Internat. Phystol., 1914, xiv, 152. 
10 Gley, E., Arch. Internat. Physiol., 1914, xiv, 175. 
11 Macleod, J. J. R., and Pearce, R. G., Am. J. Phystol., 1911-12, xxix, 
419, 
12 Oswald, A., Z. Physiol., 1915, xxx, 509; cited by Levy.'® 
13 Asher, L., Deutsch. Med. Woch., 1916, xxxiv, 1; abstr. in Physiol. Abst., 
1916-17, i, 426. 
14 Richardson, H. B., Z. Biol., 1916, Ixvii, 57. Kakehi, 8., 2bzd., 1916, 
Ixvii, 104; both papers abstr. in Physiol. Abst., 1916-17, 1, 427. 
18 Higer, M., Z. Biol., 1917, xvii, 253, 265; abstr. in Physiol. Abst., 1917, 
ii, 269. 
