THE INFLUENCE OF THYROID FEEDING UPON CAR- 
BOHYDRATE METABOLISM. III. 
THE ACIDOSIS IN EXPERIMENTAL HYPERTHYROIDISM AND ITS 
RELATION TO EPINEPHRINE IN THE BLOOD AND THE 
DECREASE OF LIVER GLYCOGEN. 
By SHIGENOBU KURIYAMA. 
ee the Sheffield Laboratory of Physiological Chemistry, Yale University, 
New Haven.) 
(Received for publication, November 26, 1917.) 
| The Influence of Thyroid Feeding upon the Hydrogen Ion Concen- 
tration and the Alkali Reserve of the Blood Plasma. 
The influence of acid and alkali upon carbohydrate metabolism, with 
respect to glycosuria, blood sugar content, and glycogen content of the 
liver, has been discussed by many investigators. Edie and his coworkers! 
reported that the glycosuria found after partial asphyxiation is due to the 
high percentage of carbon dioxide in the respired air. MacLeod? demon- 
strated that hyperglycemia and glycosuria in asphyxia and curare poison- 
ing are due to the mobilization of liver glycogen and that here the blood 
acts directly upon the liver cells without any intermediation of the nerv- 
ous system. Estimating the rate of disappearance of glycogen from pieces 
of liver, both in an atmosphere of carbon dioxide and in air or oxygen, 
he also found that glycogenolysis is more rapid in the former than in the 
latter. Administering hydrochloric acid by mouth to rabbits and also per- 
fusing turtle livers with a solution acidified with hydrochloric acid, Elias? 
demonstrated that a relatively small amount of acid can mobilize the gly- 
cogen of the liver and cause hyperglycemia and glycosuria. Studying the 
adrenal histologically, he considered that these glands have no direct rela- 
tions to the glycogen mobilization caused by acid. Elias and Kolb‘ have 
also concluded that the so called ‘hunger diabetes’’ of young dogs, is, 
in part at least, a condition due to acidosis, as indicated by the lowered 
carbon dioxide content of the blood and of the alveolar air. The word 
1 Fdie, E. 8., Biochem. J., 1906, i, 455. Edie, E. 8., Moore, B., and 
Roaf, H. E., zbid., 1911, v, 325. 
2 Macleod, J. J. R., Am. J. Phystol., 1908-09, xxiii, 278. 
3 Elias, H., Biochem. Z., 1918, xlviii, 120. | 
4Blias, H., and Kolb, L., Biochem. Z., 1918, lii, 331. 
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