S. Kuriyama 224 
TABLE IIl—Concluded. 
Blood. 
ak Body pH Pl Urine R k 
reine CL Seha ye es BEM i “Oy volume. QrDat SEs 
Before | After | capac- 
aera- aera- ity. 
tion. tion. 
Rabbit IV. Animal tissue powder feeding, 3 gm. per day. No other food. 
(Before experiment oats and greens were given freely for 7 days.) 
kg. cc. 
1 1.70 7.4| 8.1 | 55.3 62 | Urine: protein —, casts —.. 
2 55 
3 7.4 | 8.1 | 45.0 70 
4 48 
5 7.4) 8.1 | 40.9 59 | Urine: protein +, casts —. 
6 61 
7 1.40 7.41 8.1 | 38.5 45 | Died 2 days later. 
to 30.3, while on green diet the minimum was 48.8 to 46.2. . In 
one case of thyroid-fed rabbits on the oat diet, thyroid feeding 
was stopped and greens were freely given after the 6th experi- 
mental day. The CO, capacity of the plasma increased from 
29.6 to 60.7 in 2 days. In rabbits either fasted or fed with 
animal tissue powder, the CO. capacity of the plasma was also 
decreased, the former showing a more marked change than the 
latter. The minimum of the CO: capacity of the plasma was 
36.0 to 34.7 (fasted) and 38.5 to 41.3 (animal tissue powder fed). 
Judging from these results, it will be seen that in rabbits fed 
oats, thyroid feeding continued for several days caused a marked 
degree of acidosis, determined by both hydrogen ion concen- 
tration of the blood and the CO, capacity of the plasma, this 
disturbance, however, being reparable to a certain degree by tak- 
ing a large enough amount of base-forming diet; and that the 
acidosis of thyroid-fed rabbits is greater than that of fasted or 
animal tissue powder-fed rabbits. Goto! reported that acidosis 
exists in uranium nephritis. In some of my rabbits the kidneys 
seemed to be slightly impaired. As this change, if existing at all, 
was very slight, acidosis observed in my experiments is probably 
not due to the kidney injury. Acidosis in diabetes is reported to 
1? Goto, K., J. Exp. Med., 1917, xxv, 693. 
