224 Thyroid and Acidosis 
In order to see whether a diminution of the alkali reserve of 
the blood after thyroid feeding has any relation to epinephrine, 
Peters and Geyelin’s experiments were repeated on normal 
rabbits. * 
Methods.—Adrenalin (1:1,000 Parke, Davis and Company) 
was injected subcutaneously into full grown rabbits in doses of 
0.5 gm. or 1 mg. of epinephrine per kilo of body weight. Before 
the experiments some rabbits were fed on oats only, the others 
on oats and greens for 4 days. Directly before epinephrine in- 
jection the animals were fasted for 24 hours. After epinephrine 
injection the CO, capacity of the plasma was determined as de- 
scribed in the preceding chapter. The urine in 24 hours after 
- the injection was collected and its sugar content was determined 
polariscopically. The details are shown in Table III. 
TABLE III. 
The Influence of Epinephrine* Injection upon the Alkali Reserve of the Blood 
Plasma. Food in Preparatory Period (4 Days), Nos. III and 
VI Oats Only; for Others, Oats and Greens. 
Rabbitan. ea eee frosts een ae It Il III IV V VI VII 
Body Wwerghtakoue ones eke ome 2.38] 1.88} 1.70) 1.80} 1.94) 1.70) 1.72: 
Before injec- | 54.8] 63.2} 53.8] 53.9] 58.6] 48.5] 56.7 
tion. 
Plasma CO. ca- |—— | ee 
pacity. (Ce. of 3 59.5] 56.7] 50.7| 59.5: 
COs, reduced | —— ] —— } —— | — | ——— | ——_ | 
to 0°, 760 mm., 1 . 59.6] 55.7| 49.2! 59.5. 
bound as _ bi- Hr fter — | —— | —— |] ———. | | = | _—_|_—— 
carbonate by |... e 61.9] 55.6] 47.2] 60.0 
100 oe afte injection.) | js ea 
plasma.) TR 4 | 62.4] 59.5] 54.4] 63.3 
7 | 52.8] 58.6] 54.5 
Urine in 24 hrs. | Volume, ce. 137} 103} 95} 129) 116) 180) 203 
after injection. | Dextrose, gm. | 0.81] 1.47| 0.56} 0.42) 0.40) 0.39) 1.79 
* Epinephrine injection, 0.5 mg. per kilo of body weight in Rabbits I ~ 
to VI; 1.0 mg. in No. VII. 
+ The sugar content of the blood before epinephrine injection, and 2, 
4, and 7 hrs. after epinephrine injection respectively was 0.13, 0.33, 0.25, 
and 0.15 per cent. 
