226 Thyroid and Acidosis 
some experiments on the influence of alkali upon the decrease of 
the liver glycogen of thyroid-fed animals. 
Methods.—Desiccated thyroid was given to albino rats in doses 
of 1 gm. per day for 4 days. As the main food, dog biscuit-lard 
paste was used. 0.8 to 0.4 gm. of sodium bicarbonate was mixed 
with the food every day. When a larger amount of bicarbonate 
was given, the animal refused to eat it. On the 4th day 1 or 2 
em. of sucrose was given in some cases. In the morning of the 
5th day, the liver glycogen was determined: The results are 
shown in Table IV. 
TABLE IV.. 
The Influence of Sodium Bicarbonate upon the Decrease of Liver Glycogen of 
Thyroid-Fed Rats. 
22:) Pee ey ee sah CE Der rncr aa Meanie tants on I II Iit IV Vv 
Body weight; gmteioee ae face eee 255.7| 218.6] 217.4 | 209.6] 230.1 
Ist day. Paste, gitas.a) 6S 0% 6. Ui one 6.6} 4.5 
NaHCOs, gm.| 0.3} 0.3) 0.4 0.44 0.4 
2nd day. | Paste, gm.... 6.9) t. 6° 6) rie 6.0} 6.0 
NaHCoO;, gm.| 0.3} 0.3) 0.4 0.4) 0.4 
Desiccated = | |__| _ |__| 
thyroid 3rd day. | Paste, gm.... 6.8) ) (6.0 BSGke 6:6)) +620 
1 gm. + NaHCoOs, gm. 0/3 0.3 0.4 0.41 0.4 
Paste, gm.... 6.9| 6.8 6.9 6.4, 8.0 
Ath day. | Sucrose, gm.. 0 1k. GO) 466 ZOMG 
NaHCoOs;, gm.| 0.3} 0.3] 0.4 0.4) 0.4 
Calories......| 38.6} 42.2) 88.6] 44.3) 44.1 
Loss of body weight, gm... .-:2 9. en —8.8/—25.8)—24.0 |—21.5)—21.5 
Weights.gi7 ict eee 9.4, 6:8) 65 Dane eO2S 
: [9g ier eee} 10.9 23.4 
Liver. phe 0 nee 0 
Veh DEL CEN ame 0.2 0.4 
From this table it will be seen that under the experimental 
conditions employed, an oral administration of a relatively small 
amount of sodium bicarbonate does not specially modify the de- 
a ‘ 
