258 Studies in Metabolism. I 
after the injection and usually continues several hours. Twelve 
of the twenty-one died following the injection; some of them sey- 
eral hours after injection with typical convulsions, most of them 
during the following night, while a few of them died within a few 
days. In all cases the condition of the cage showed that the ani- 
mals died in convulsions. Although the cases in which hypo- 
TABLE III. 
First Injection of Guanidine. 
: g g Blood sugar. 
z ge 
a Date. Weight. ks c A F 4 : F F est 
= cae 12 os a a, Q, Q at 
ee Om 2 = = 2) od 20 Peo 
1917 gm. gm. |per cent|per cent\per cent|per cent|per cent|per cent|per cent 
23-| Aug. 15} 1,960 | 0.30 | 0.115 0.178 
21 i 8} 1,520 | 0.25 | 0.093} 0.098} 0.080) 0.058} 0.056) 0.053 
22 “  -14| 2,080 | 0.25 | 0.107} 0.116) 0.103} 0.106) 0.098} 0.073} 0.070 
24 y 17) 1,88070.25 | 02411 0.189} 0.100} 0.073} 0.024 
31 | Sept. 29] 1,400 | 0.20 | 0.117 0.057) 0.048 
30 eC TL GOOMMO eZ te Oe Lito 0.080} 0.072) 0.068 
29 Oi 201-2540 150220 1 OT 0.084} 0.083} 0.067} 0.100 
27 | Aug. . 24! 2,600 | 0.20 | 0.120 0.053 
26 ee Zot 1,600 )) (02209) 209120 0.099} 0.111) 0.043 
18 4 5) 1,520 | 0.20 | 0.118} 0.143) 0.132} 0.103} 0.057) 0.039) 0.086 
14 | July 22) 1,740| 0.20 | 0.120} 0.123) 0.104} 0.069) 0.074) 0.057) 0.105 
15 ms 23) 1,520 | 0.20 | 0.100) 0.105) 0.094) 0.067; 0.081} 0.073} 0.095 
19 | Aug. 6) 1,920} 0.20 | 0.110) 0.143) 0.147) 0.110) 0.115} 0.094) 0.100 
25 “<-23} 2,000 | 0.20 | 0.200)’ 0.108} 0.118) 0.103 
28 | Sept. 27) 2,300 | 0320 10.125 0.127) 0.167} 0.129) 0.129 
10 ; July 18) 4,700) 0.15 | 0.118) 0.148) 0.134) 0.074) 0.065) 0.056; 0.111 
12 - 19) 1,480 | 0.15 | 0.104} 0.127} 0.112} 0.116} 0.115} 0.080; 0.101 
13 - 21) 1,520 | 0.15 | 0.103} 0.113) 0.115) 0.120) 0.113) 0.092) 0.096 
16 24! 1,300 | 0.10 | 0.111] 0.122) 0.119) 0.114) 0.107) 0.094; 0.120 
17 4 29| 1,900 |.0.05 | 0.122) 0.123) 0.123) 0.129} 0.117) 0.100} 0.116 
20 | Aug. 7/| 1,440] 0.05 | 0.103) 0.105) 0.102} 0.107] 0.099} 0.102) 0.104 
glycemia occurs usually terminate fatally, three rabbits showing 
hypoglycemia recovered. The dose which was injected in this 
group varied from 0.05 gm. to 0.3 gm. per kilo of body weight. 
None of the rabbits that received under 0.1 gm. per kilo of body 
weight showed hypoglycemia and by careful inspection of the 
table it will be observed that the hypoglycemia provoked is almost 
