260 Studies in Metabolism. I 
shows hypoglycemia and this appears just before the fatal ter- 
minal convulsion. There was marked hyperglycemia for a few 
hours after injection in this group of rabbits and only No. 19 
recovered. There was no sugarin the urine. It is worthy of note 
that Rabbit 19 was injected five times at intervals of 1 or 2 
TABLE V. 
Third Injection of Guanidine. 
é ey g Blood sugar. 
} os 
‘ out | eo = Next 
® Date. Weight. te a p F F J F F ye 
2 Si 2 @ 3 2, Q, a at 
la Claw Ae o> ra “_N i=) oO 9 a.m 
1917 gm. gm. |per cent|per cent|per cent\per cent|per cent a cent|per cent 
3 | July 12) 23500) 0.25 | 0.122). 0.169) 0.145) 0.143) 0.109) 0.119 
11 80} 2,100 | 0.30 | 0.105) ° 0.078 
16 | Aug. 10) 1,120} 0.30 | 0.108) 0.200) 0.204) 0.148; 0.131) 0.122) 0.111 
dy ss 11} 1,780 | 0.380 | 0.115 0.221) 0.182} 0.133) 0.108) 0.141 
19 ‘ 28) 1,880 | 0.25 | 0.121} 0.200} 0.167; 0.137) 0.124; 0.111) 0.104 
TABLE VI. 
Five Experiments with Rabbit 19. ° 
sey ge Blood sugar. 
: - : 
. | Date. |Weight. a3 : F P : F F F es 
oe) ao 2 3 is 2, a, a, = at 
iA =] Ye 
gQ ont aR [=>) = ios) H wD co 9 a.m 
1917 | om: | om. | Zone \-cent 4 cent | cent | cote \ecer ie ane 
1 Aug. 6) 1,920} 0.200.1100.143)0.147/0.111 0.115/0.094)0.100 
2 rf 13! 1,400 Do ae 0.154'0.125 0.122)0.107\0.111 
3 A 28) 1,880 | 0.250.121,0.2000.167|0.137 0.124/0.111/0.104 
4 Sept. 11) 1,850 | 0.25)0.113 0.133 0.084'0.064 0.091/0.088'0. 127 
o % 25; 1,800 | 0.250.119 0 .087|0.067\0.070 0.100 
weeks and that no hypoglycemia occurred the first three times. 
The fourth and fifth injections provoked a marked hypoglycemia. 
Duration of Hypoglycemia Which Is Induced by Guanidine 
Administration. 
Usually the hypoglycemia appears 7 hours after injection of the 
drug and continues several hours through the night which fact 
makes it impossible to take samples until the next morning when 
