Variation of Total Solid and Sugar Percentage in 
Rabbit No, 
C. K. Watanabe 263 
guanidine. One other rabbit was used also which later was in- 
jected twice more. One sample for comparison was taken before 
injection. In some animals the dose is not large enough to pro- 
duce hypoglycemia. In those animals in which hypoglycemia 
appeared the total solids in the blood remained normal. It is 
worthy of note that the variation in total solids in the same rab- 
bit is practically the same in experiments tabulated in Table 
VIII as in those in Table IX. In Rabbit 19 hypoglycemia 
appeared only after the second and third injection when the total 
solids remained the same as after the first injection. 
TABLE IX. 
dine Injection. 
Blood before and after Guani- 
ass 7a.m 2 p.m 3 p-m 4 p.m. 5 p.m. 8 p.m. 
238 
Date. g E> ; : : 5 ; ; 
Deere em og ae loa his iia lac okeorl as ia 
O.2S6SB mM mM M o COR he) mM mM wa M io) op) 
elie este ice eh cent| cont, cont |oaene. cont | cent \'cont | cen, \'cent 
Aug. 23) 0.20 |0.200)15.1/0.108/16.3 0.118)15.5)0.103)14.4 
“24, 0.20 |0.120)16.9,0.053)18.5 
Sept. 27} 0.20 |0.125]15.2 0.167|14.80.129)14.5 
s 27| 0.20 |0.111/16.5)0.084 0.087|16.0 0 .083)15 .4/0.067/15.0 
“ -- 29) 0.20 |0.115]16.0,0.080)15.8 0.072/14.60.068/13.9 
*.29| 0.20 |0.117115.5|0.057/15.9 0.048)17.5 
Aug. 24) 0.25 |0.121/15.4/0.187|15.3 - 10.124/14.4/0.111/13.7 
Sept. 11} 0.25 |0.113|16.4'0.064/16.2 0.091)15.2/0.088)15.4 
is 25) 0.25 |0.119}16.5 0.069)17 .3,0.070/16.9 
Tetania parathyreopriva and idiopathic tetany are almost 
identical in the character of their symptoms, such as electric ex- 
citability, increased mechanical excitability, depression, emacia- 
tion, spasticity, tremor, convulsion, laryngeal spasm, etc., ac- 
cording to many workers. According to Burns (22) there is a 
striking resemblance between the metabolic evidences of tetania 
parathyreopriva and the injection of guanidine. Burns and 
Sharpe (13) demonstrated the increased guanidine base in the 
urine of children which manifested symptoms of idiopathic tet- 
any and also in the urine and blood of animals which had symp- 
toms of tetania parathyreopriva. , Moreover, the serum of para- 
