278 Studies of Acidosis. X 
sults calculated by the two equations is, however, so small that 
the remarks on the range of error in such calculations made in 
Papers IV and VI hold with essentially equal force when the 
simplified formula is used. Further simplification, by neglecting 
the body weight or titratable acid as suggested by Barnett, de- 
creases the accuracy of the estimation. 
For practical purposes the acid excretion may, without going 
through the calculation of the formula, be interpreted directly 
into terms of clinical severity of acidosis, as indicated in the table; 
€.g., an excretion exceeding 27 cc. of 0.1 N ammonia plus acid 
per kilo indicates acidosis, which usually becomes critical if the 
excretion approaches 100 cc. per kilo. 
The relationships of the plasma bicarbonate to acid excretion, 
alkali retention, and alveolar carbon dioxide tension are sum- 
marized for reference in a table, wherein are also indicated the 
chief errors to which, according to the data of Papers IV, VI, 
and IX of this series, the three latter determinations are sub- 
ject as measures of diabetic acidosis. 
BIBLIOGRAPHY. 
1. Barnett, G. D., J. Biol. Chem., 1918, xxxiii, 267. 
2. Fitz, R., and Van Slyke, D. D., J. Biol. Chem., 1917, xxx, as82 3 Fitz 
collaboration in the present paper is prevented by his absence on 
military service. 
3. Stillman, E., Van Slyke, D. D., Cullen, G. E., and Fitz, R., J. Biol. 
Chem., 1917, xxx, 405. 
4. Magnus-Levy, A., Arch. exp. Path. u. Pharm., 1899, xlii, 149. 
. Palmer, W. W., and Van Slyke, D. D., J. Biol. Chem., 1917, xxxii, 499. 
. Peters, J. P., Proc. Soc. Exp. Biol. and Med., 1916-17, xiv, 118. 
o> Or 
