_ 300 CO, Capacity of Blood. II. 
Experiment 5.—Dog, male, 12 kilos. Light and irregular etherization 
followed by very deep etherization (with no rebreathing). Equilibrating 
air 5.65 per cent COs. 
; Blood CO». 
Time. Condition. RECS, i 
t ah Capacity. 
p.m. ee a vol. per cent 
3.00 |. zi 49 50 
3.15} Ether started. 
3.45 82 39 47 
4.15 . 73 37 42 
4.45 57, 38 43 
0.15 61 36 40 
5.45 63 39 39 
6.00 | Ether increased to limit. 
6.15 47 43 39 
6.45 | Blood dark. 37. shallow. |. 53 41 ° 
7.15 * af 46 “< 67 54 
7.23| Dog dead. 
From this experiment it is clear that when the CO, content is 
lowered by etherization the effect is not due to any influence of 
the ether per se other than the excessive pulmonary ventilation 
and low alveolar CO.. In order however to make absolutely 
sure of this point we performed Experiments 6 and 7. We 
reasoned that if ether acts in some obscure way upon metabolism 
to induce “acidosis”? (the opinion now widely held), then the 
more ether administered the greater should be the so called 
acidosis and the lower the CO.-combining power. As ether in 
low concentrations excites and in high concentrations depresses 
respiration, it was easy to frame a crucial experiment. ‘Thus in 
Iixperiments 6 and 7 an etherization so profound was maintained 
that-respiration was depressed and the CO, content rose instead 
of falling. As the protocols show the CO, capacity followed up- 
ward, rising from 50 to 61 in one case, and from 47 to 60 in the 
other. 
