McCollum, Simmonds, and Parsons 423 
patent flour, and cottonseed oil, which was employed throughout 
this work. All suffered steady decline, showing that the diet is 
not of a character to support either maintenance or growth 
until properly supplemented. Three of the six animals died at 
the end of the 8th, 12th, and 15th weeks respectively. 
The coats of these animals became rough but there were no 
thickening of the ears, baldness, soreness of the tails, or cutaneous 
horns on the noses, such as we have seen to be concomitant with 
faulty diet. We have not observed therefore, the pathological 
changes in the mucous surfaces of the alimentary tract nor the 
skin changes and infections observed by Chittenden and Under- 
hill in dogs. In grown rats, loss of weight and the early appear- 
ance of senile characters were the only evidences that this diet 
was inadequate. In certain groups (Charts 1 and 2) in young 
rats skin changes were observed. 
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