Schmidt, von Adelung, and Watson 503 
TABLE III. 
Subject 8. 
Day of experiment. anie real eee re Remarks. 
gm. gm. gm. gm. 
1 0.448) 0.031} 0.057} 0.544 
2 0.404) 0.029} 0.099} 0.531 
3 0.419) 0.042) 0.130} 0.591 
Averages..... 0.424) 0.034} 0.095) 0.555 : 
4 0.439) 0.035} 1.751) 2.225} 10 gm. of taurin (S = 2.48 
gm.) subcutaneously. 
5 0.444) 0.044) 0.132) 0.619 
6 0.499) 0.053] 0.101) 0.652 
7 0.706) 0.044) 1.238) 1.988) 10 gm. of taurin (S = 2.48 
gm.) by mouth. 
8 0.516) 0.048) 0.127) 0.692 
9 0.468} 0.029) 0.119) 0.615 
10 0.417} 0.030} 2.006} 2.453} 10 gm. of taurin (S = 2.63 
gm.) intravenously. 
11 0.492} 0.031} 0.202) 0.725 
12 0.560! 0.026} 0.152| 0.739 
13 0.535] 0.032 0.109) 0.676 
tion in the sulfur content of the diet of Subject 3 the sulfur out- 
put for the 3rd day following the taurin administration is taken 
as the normal value for that period. This gives a percentage 
recovery of the taurin sulfur in the urine, when given subcutane- 
ously, by mouth, or intravenously, as 62, 59, and 72 per cent 
respectively. These figures compare favorably with those re- 
ported by Salkowski. Pending the development of an easy 
method for determining the forms of neutral sulfur on which work . 
is under way, we give no results as to the amounts and nature 
of the compounds by which taurin is excreted in the urine. 
It should also be noted that contrary to the findings of Salkow- 
ski, no symptoms which could be attributed to the administra- 
tion of taurin were shown by the human subjects with the doses 
given, or even when larger amounts were employed. Large 
amounts may also be given intravenously to rabbits without 
toxic effect. 
THE JOURNAL OF BIOLOGICAL CHEMISTRY, VOL. XXXIII, NO. 3 
