Society of Biological Chemists Xl 
FURTHER STUDIES IN AUTOLYSIS. 
By H. C. BRADLEY. 
(From the Laboratory of PhysiologicalChemistry, University of Wisconsin, 
Madison.) 
I. Brain—The autolysis of nervous tissue is accelerated by 
acids and inhibited by alkali just as are other gland tissues. 
While the amount of protein present in nervous tissue is very 
small, the rapidity of its autolysis is about equal to that of 
liver or kidney. Because of the exceedingly delicate protein 
framework of the nerve cell, its destruction through the auto- 
lytic mechanism may quickly proceed to an irreparable extent, 
while other organs with their large protein content may undergo 
large atrophic changes without irreparable damage. — 
II. Muscle—Of the three types of muscle tissue, striated auto- 
lyzes most slowly and to the smallest extent. Cardiac and smooth 
muscle autolyze from 50 to 100 per cent faster. All three are 
found to be accelerated by acidity and inhibited by alkalinity, 
but to a much less striking extent than the gland tissues pre- 
viously studied. 
ITI. Collocds—The work of Ascoli and Izar on the accelerating 
action of inorganic hydrosols on autolyzing liver was repeated, 
but not confirmed. Sols of silver, gold, and platinum, prepared 
by the Bredig method, were found to be wholly inert, neither ac- 
celerating nor inhibiting autolysis. Colloidal Fe(OH)3, AseSs, 
and Sb.S3 when dialyzed free from electrolytes were found equally 
inert when added to autolyzing liver pulp. The disagreement 
between these results and those of the above mentioned authors 
is so complete that further experiments are under way. 
THE INFLUENCE OF MECHANICAL WORK UPON PROTEIN ME- 
TABOLISM DURING THE HEIGHT OF MEAT DIGESTION 
IN THE DOG. 
By H. V. ATKINSON. 
(From the Physiological Laboratory, Cornell University Medical College, 
New York City.) 
A dog was given 600 gm. of meat daily in one portion, and 
the nitrogen eliminated in the urine during the 4th, 5th, and 
