Society of Biological Chemists XV 
The following table gives the résumé of the experiments: 
(1) Average normal excretion of hippuric acid nitrogen per 24 hours. 
Et eT. RO RET, Neb hte Wee oe ae! CETERA ERO ds 5 Ss 0 .029 
Reh ic. eT Gh a Bae Br ty ls WG RE PERE ae 6g 0.032 
(2) Average excretion after the administration of 2 gm. of sodium benzoate 
by mouth. 
[tet ARI ee 8 Ni a eR at os 0.082 
Pe. cic LA Cen Ceakea Cae eae NEE Bud ee eG 0.069 
(3) Average excretion after administration of hydrazine sulfate by mouth. 
LEGER IO ne Oe on NLL a ee 0.043 
Rls es 3 ee Erato ta cet acid.) Be ol CN 0.045 
(4) Average after injection subcutaneously of 500 mg. of hydrazine sulfate. 
Ere cee Ope nat ire ects ee RIAL ek ec Seen kstrs ats in 6G 0.026 
TEAS 3 Nee nag oh: pea eae? ES oy aes he ee Se ee 0.030 
(5) Average after following this injection with 2 gm. of sodium benzoate 
by mouth. 
gt SS a OA Serre coe gte-  ce) Ohh eran a, War ae Aa ae Be 0.015 
RPE eM rade ue ate oc aos, 3 oh ws de Aevee EOS Sia luy yee 0.014 
Averages of the two dogs. 
ee Ce ee ae en es ee aa eae oe Sree lee Gee 0.030 
RN eer Ee saws a AE Re es as bee 0.075 
zs Bay tur tote Se Pe ee eee, EP Ogee Re 0.044 
oi EES ATS SoC E OU Re ea re, 0.028 
va Pry sere MM atic ald shales 4 a tele «ns 0.014 
From these figures, it is evident that normally, an increase in 
hippuric acid nitrogen after giving sodium benzoate by mouth 
- occurs; that after giving hydrazine by mouth, the hippuric ex- 
cretion was not affected; that no effect was observed upon the 
administration of hydrazine subcutaneously, but that after hy- 
drazine wnjection followed by sodium benzoate by mouth, less hip- 
puric acid vs excreted. 
The kidneys gave every evidence of being normal, as judged 
by the chloride excretion day by day and also by the condition 
of the kidney at autopsy. Professor Oscar T. Schultz, director 
of the Institute, kindly performed the autopsy and reported that 
Dog II gave wholly normal histological pictures, while Dog 1 
showed some glomeruli and interstitial capillaries engorged, but 
no other indication of lesion. The livers, on the other hand, 
showed marked fatty degeneration with central congestion and 
central necrosis. It is to be concluded, then, that in the dog 
