1 Sepr., 1901.] QUEENSLAND AGRICULTURAL JOURNAL. 341 
Quinine, which gives such happy results in human malarial fever, is utterly 
insufficient for bovine malaria. 
At the beginning of the disease, or during its course, I have used sub- 
cutaneous injections of sulphate and chlorohydrate of quinine in doses of one, 
two, five,and up to ten grammes daily, without the animal deriving any benefit 
whatever from it. Rather, the preventive injections have proved utterly 
-inefficacious. The animals injected with quinine for two or three days, and 
which afterwards received a virulent injection, took the fever with the same 
delay and with the same gravity as the controls. 
Example :— 
_ On September 10 a bullock received sub-cutaneously ten grammes of sulphate of 
uinine. 
: On the 11th and 12th I renewed the injection. On the 13th it was inoculated sub- 
cutaneously in the connective tissue, with one quarter of a cubic centimetre of virulent N= 
blood, at the same time as a control. : 
September 14th.—Temperature, 38°8 C. 
f 15th - 38°8 C. te 
i$) 16th r 38°8 C. i — 
” 17th 3) y9°2 C. He 
+ 18th Fi 39°3 C. Up to this day I found nothing in ihe he 
corpuscles; it was the same with the Ae 
control. = 
7 19th iy 38°8 C. Very few Piroplasma ; I found none in 
the control. 
a 20th +" 39°6 C. Hematozoa are easily detected; I 
found a few stray ones in the control. 
P 21st _ 41°4C. The urine is deep red, the hematozoa 
very numerous; the control is not 
so ill. 
i 22nd 5, 40°5 C. Urine red, animal very depressed ; many 
hematozoa. The urine of the control 
is red, and its temperature high 
(40°7 (). 
September 23rd.—Temperature, 39°6 C. Urine deep red; hematozoa less 
numerous. he control appears to be doing equally well. 
September 24th.—Temperature, 38°8 C.; control, 38°5 C. Both have become con- 
valescent. The animal which received the preventive treatment with quinine has been 
a little worse than the control. 
I have also exhibited quinquina as a drench}+ without obtaining any 
appreciable result. As may be seen by the action of quinine, the micro-organism ¥ 
of bovine malaria is different again from the hematozoa of Laveran. ie 
I have also used methylene blue, 3 to 5 grammes in pills; salicylate of soda 
in doses of 10, 20, 30 up to 50 grammes daily ; arsenious acid, 2 to 5 grammes in 
twenty-four hours ; cacodylate of soda in sub-cutaneous injections—O gr. 50— 
without effecting any more cures than if I had left the animals untreated. 
Chloride of sodium—common salt—and purgatives in general, have appeared to —_ 
give good results, because they were specially used for the obstinate constipa- i 
tion which comes on at the moment of convalescence. Perhaps, in these cases, ku 
the purgatives help the organism to rehabilitate itself quicker. ia 
Blood-letting and mustard poultices succeeded with a certain number of ‘A 
patients and remained without effect in others. 
To sum up, we have, up to the present day, no mode of treatment truly 
efficacious and worthy of being employed above all others. On the contrary, 
it is acting wisely to keep the diseased beasts away from all excitement, and as 
much as possible, in summer, to shelter them from the rays of the sun. Violent 
efforts and forced marches are aggravating circumstances of the first order. 
Ihave often seen bulls die shortly after a painful march of from 4 to 500 
metres. 
The affected animals should be given food which is refreshing and easy of 
digestion—green food for preference. 
td pea pones of quinine, 10 grammes ; distilled water, 100 grammes; tartaric acid,.5 grammes, 
Dissolye by heat. 
+ 20, 50, or 100 grammes of powdered quinquina, 
