el ee Te 
1 Noy., 1901.] QUEENSLAND AGRICULTURAL JOURNAL. 505 
As for the control, bull No. 5, he behaved in a totally different manner. 
From the 15th to the 20th all went well, and it would have been impossible, 
even on the evening of the 20th, to say that on the following day he would be 
found ina most alarming condition. During these five days the temperature 
was perfectly regular between 88 degrees C. and 39 degrees CO. (101 degrees 
Fahr. and 103 degrees Fahr.); food and drink were taken with a good 
appetite. 
Suddenly, during the night of 20th to 21st July, the temperature rose 
from 383 degrees CO. to 40:4 degrees C. (101 degrees Fahr. to 105 degrees 
Fahr.). The appetite almost entirely ceased, but, notwithstanding this violent 
reaction, the animal remained strong and sprightly, and the ure was still of 
the normal colour. 
On the 22nd the temperature rose to 40°7 degrees C. (105’6 degrees Fahr.), 
food was utterly refused, the sick beast was more depressed, the urine 
appeared slightly coloured, but as yet only few hematozoa were found in the 
blood. 
On the 28rd the temperature rose to 41°2 degrees C. (106 degrees 
Fahr.). The depression was extreme. All nourishment was absolutely refused 
the urine was of a pronounced red colour, and passed rapidly to brown when 
exposed to the atmosphere. The examination of the blood revealed the presence 
of a large number of piriform hematozoa. The enumeration of the red 
corpuscules, which was performed by Mons. Nocard at 2°30 p.m., showed only 
3,0U0,000, that is to say, less than half the normal number. At 6°30 p.m. there 
were only 1,000,000. oa 
I fully expected, from what I had already seen, that the patient would die 
during the night. In the course of May and June, Mons. Lignitres had 
jnoculated two sick beasts for my use, and I had seen them die of high fever 
(hyperthermia) and with symptoms so similar to those exhibited by our control 
that I predicted a post-mortem for the following morning. 
Contrary to all expectation, on the morning of the 24th, the general 
condition appeared to be stationary. The animal still refused food, it appeared 
greatly constipated, the muzzle remained very dry, the urine was of a still darker 
.colour than on the previous evening, of the colour of black-currant juice, and 
‘an enumeration of the red corpuscules only showed 870,000 per cubic 
millimetre. 
Only a few micro-organisms were now found in the blood, and these were 
.of rounded shape, no longer piriform. 
On the other hand, the temperature underwent a sudden fall of almost 
‘3 degrees ©. (25 degrees Fahr.). From 41:2 degrees C. (106 degrees Fahr.) 
it fell to 38°3 degrees OC. (101-4 degrees Fahr.). 
Mons. Ligniéres anticipates a favourable termination following a very 
virulent attack of the disease. ‘This is what appears in reality to be the case. 
Yesterday evening the patient took some drink. This morning, 25th July, 
-a perceptible and clearly evident improvement showed itself. The temperature 
‘remains low, 38'4 degrees C. (101'4 degrees Fahr.) ; the muzzle is almost cool; 
-the patient drinks willingly, and tries to eat a little. A favourable termination 
“is therefore probable. 
Now, gentlemen, the disease caused by the piroplasma, whilst often 
-causing great ravages in Argentina, is not fatally mortal. It is not, therefore, 
an exceptional case that our control survives. 
That which must be remembered in the experiment which I have just 
reported is that, without the least doubt, the vaccination as practised by Mons. 
Lignitres has been shown to be absolutely efficacious. The two subjects 
syaccinated were not even inconvenienced in the slightest degree, whilst the 
-control was so sick that it might have been considered as lost. 
The demonstration appears then to be perfect, and, from a practical 
-standpoint, no more are required. 
