Nineteen new species of Desmopachria Babington, 1841 are described from multiple species groups. Two new species groups are erected, the Desmopachria apicodente species group and the Desmopachria bifurcita species group. Desmopachria divergenssp. nov. (Venezuela), Desmopachria lineatasp. nov. (Venezuela), Desmopachria surinamensissp. nov. (Suriname), and Desmopachria tenuasp. nov. (Guyana) are described in Desmopachria but are not assigned to a species group. Desmopachria apicodentesp. nov. (Guyana, Venezuela), Desmopachria lateralissp. nov. (Venezuela), and Desmopachria tumidasp. nov. (Venezuela) are described in the new Desmopachria apicodente species group and are the only members of the group. Desmopachria bifurcitasp. nov. (Peru), and Desmopachria latasp. nov. (Brazil) are described in the new Desmopachria bifurcita group. Other members of the Desmopachria bifurcita group are Desmopachria bifasciata Zimmermann, Desmopachria bolivari Miller, Desmopachria ovalis Sharp, and Desmopachria varians (each previously “ungrouped”). Desmopachria pseudocaviasp. nov. (Venezuela) is described in the Desmopachria convexa-signata species group. Desmopachria wolfeisp. nov. (Venezuela) is described in the Desmopachria nitida species group. Desmopachria angulatasp. nov. (Guyana, Suriname), Desmopachria emarginatasp. nov. (Guyana, Suriname, Venezuela), Desmopachria imparissp. nov. (Guyana), Desmopachria impunctatasp. nov. (Suriname, Venezuela), and Desmopachria truncatasp. nov. (Guyana, Suriname) are described in the Desmopachria portmanni-aldessa species group. Desmopachria bisulcatasp. nov. (Suriname), and Desmopachria irregularasp. nov. (Venezuela) are described in the Desmopachria portmanni-portmanni species group. Desmopachria robustasp. nov. (Venezuela) is described in the Desmopachria striola species group. A key to the species groups is included. Male genitalia are figured for all new species and dorsal habitus images are provided for most new species.
