Invasive species have substantial ecological and economic costs and removing them can require large investments by management agencies. Optimal spatial allocation of removal effort is critical for efficient and effective management of invasive species. Using a series of ecologically informed model simulations, we evaluated and compared different spatially explicit removal strategies for invasive rusty crayfish (Faxonius rusticus) in the John Day River, USA. We assessed strategies in terms of their performance on three likely management objectives: suppression (minimise overall population abundance), containment (minimise the spatial extent of invasion) and prevention (minimise spread into a specific area). We developed five spatial removal strategies to achieve those objectives, denoted as: Target Abundance (removal at locations with the highest population abundance), Target Growth (removal at locations with the highest population growth), Target Edges (removal at the most distant locations in the river), Target Downstream (removal at the most downstream invaded segments on the Mainstem), and Target Random (removal at randomly selected locations). Each strategy was assessed at various effort levels, referring to the number of spatial segments in the river in which removals were conducted, after seven years of management. We identified the alternative that best achieved each objective, based on decision criteria for risk-neutral and risk-averse decision-makers and further evaluated strategies based on Pareto efficiency, which identifies the set of alternatives for which an improvement on one objective cannot be had without a decline in performance on another. We found that Target Abundance and Target Growth strategies best achieved the suppression objective, for risk neutral and risk averse decision-makers, respectively and Target Downstream was always best in achieving the prevention objective across both types of decision-makers. No single strategy consistently performed best in terms of the containment objective. In terms of all three objectives, Target Downstream was consistently Pareto efficient across all levels of management effort and both decision criteria. The modelling framework we provided is adaptable to a variety of riverine invasive species to help assess and compare spatial management strategies.