Modulation of immune responses by the tumor suppressor p53

By

Lowe, Julie
Shatz, Maria
Resnick, Michael
Menendez, Daniel

Type

Article

Date of Publication

2013-5-31

Original Publication

Biodiscovery

Volume

8

Series / Issue

Issue: 8

Pages

1--12

Subjects

Immune system , Inflammation , NF-kB , p53 , transcription factor , virus

Contributed by

Pensoft Publishers

Language

English

Published by

Newport on Tay Scottish Science Press

Identifiers

DOI: https://doi.org/10.7750/BioDiscovery.2013.8.2

 

Abstract

The commonly held view of the tumor suppressor p53 as a regulator of cell proliferation, apoptosis and senescence has expanded greatly in recent years to cover many biological processes as well as external and internal stress responses. Since the discovery over 30 years ago of p53 as a cellular protein that co-precipitates with the large T antigen of Simian Virus SV40, there has been an intertwining of p53 activities with immune-related processes, especially as relates to cancer. A variety of interactions between the p53 and the immune stress systems are currently being addressed that suggest opportunities to utilize p53 in modulating immunological activities. Here, we discuss those interactions along with implications for human disease.