Does positioning of chromosomes 8 and 21 in interphase drive t(8;21) in acute myelogenous leukemia?

By

Othman, Moneeb
Lier, Amelie
Junker, Susann
Kempf, Philipp
Dorka, Franziska
Gebhart, Erich
Sheth, Frenny
Grygalewicz, Beata
Bhatt, Samarth
Weise, Anja
Mrasek, Kristin
Liehr, Thomas 1965-
Manvelyan, Marina

Type

Article

Date of Publication

2012-10-

Original Publication

MycoKeys

Volume

4

Pages

1--5

Subjects

chromosome 21 , chromosome 8 , fluorescence in situ hybridization (FISH) , formation of chromosome aberrations , interphase chromosome (genome) organization

Contributed by

Pensoft Publishers

Language

English

Published by

Sofia, Bulgaria Pensoft Publishers 2011-

Identifiers

DOI: https://doi.org/10.7750/BioDiscovery.2012.4.2

 

Abstract

The impact of chromosome architecture in the formation of chromosome aberrations is a recent finding of interphase directed molecular cytogenetic studies. There evidence was provided that disease specific chromosomal translocations could be due to tissue specific genomic organization. In a recent small pilot study using three-dimensional interphase fluorescence in situ hybridization, we showed that there might be a specific chromosome positioning in myeloid bone marrow cells, i.e. a co-localization of chromosomes 8 and 21. Here we could substantiate this finding in overall 21 studied cases with acute myeloid leukemia (AML) that there is even a co-localization of the genes AML1 and ETO. This finding led to the suggestion that a specific interphase architecture of myeloid bone marrow cells might promote the typical t(8;21)(q22;q22) leading to AML-M2.