Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients

By

Tummala, Hemanth
Goltsov, Alexey
Khalil, Hilal
Sproul, Anne
Scott, Fiona
Mitev, Vanio
Zhelev, Nikolai

Type

Article

Date of Publication

2012-12-

Original Publication

Biodiscovery

Volume

6

Series / Issue

Issue: 6

Pages

1--15

Subjects

B-CLL , Cancer , Systems biology

Contributed by

Pensoft Publishers

Language

English

Published by

Newport on Tay Scottish Science Press

Identifiers

DOI: https://doi.org/10.7750/BioDiscovery.2012.6.4

 

Abstract

The clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival? In recent years, mathematical modelling has contributed significantly in understanding the complexity of diseases. In order to build a mathematical model for determining prognosis of B-CLL one has to identify, characterise and quantify key molecules involved in the disease. Here we discuss the need and role of mathematical modelling in predicting B-CLL disease pathogenesis and suggest a new systems biology approach for a personalised therapy of B-CLL patients.