Small molecules and human cardiomyogenesis: Is there a bottleneck in current research?

By

Doflein, Franz, 1873-1924
Trifonov, Dimitar

Type

Article

Date of Publication

2015-3-31

Original Publication

Biodiscovery

Volume

15

Series / Issue

Issue: 15

Pages

1--6

Subjects

cardiomyogenesis , Differentiation , human pluripotent stem cells , small molecules. , stem cell-derived cardiomyocytes

Contributed by

Pensoft Publishers

Language

English

Published by

Newport on Tay Scottish Science Press

Identifiers

DOI: https://doi.org/10.7750/BioDiscovery.2015.15.2

 

Abstract

Human pluripotent stem cell derived cardiomyocytes (hPSC-derived CMs) have a vast potential in drug discovery, disease modeling and regenerative medicine. In recent years various differentiation protocols for hPSC-derived CMs have been developed. Most of them utilize the modulation of human cardiomyogenesis via small-molecule compounds. However, setbacks to the large-scale application of hPSC-derived CMs still abound: insufficient insight into important signaling pathways for cardiac lineage-specific differentiation and identification of suitable small-molecule modulators; inconsistent results due to unstandardised culturing techniques; lack of effective maturation of hPSC-derived CMs in vitro. So is there a bottleneck in current research? This paper attempts to answer this question.